Impact of Glucose Variability on Hospital Mortality in Non-Diabetic Septic Patients: A Novel Insight from Original Research

Abstract

Background

 Severe sepsis is a potentially fatal illness that necessitates critical care due to organ failure. It has been determined that glucose variability (GV) may play a role in hospital mortality, especially in non-diabetic septic patients. In non-diabetic septic patients, our study examines the relationship between hospital mortality rates and glucose fluctuation.

Materials & Methods

 In the Department of General Medicine at Sree Balaji Medical College and Hospital in Kancheepuram, Tamil Nadu, India, a prospective observational study was carried out , over an 18-month period beginning in November 2022. We enrolled 100 randomized patients, with 50 patients presenting with sepsis and 50 non-septic patients as controls. Glucose variability was assessed using blood glucose measurements, and its association with mortality was analysed using logistic regression, adjusting for potential confounders including organ failure, glucose testing, and medication.

Results
According to our research, non-diabetic septic patients with high glucose fluctuation had higher hospital mortality rates. Compared to patients with more stable glucose levels, individuals with greater variations in their levels of glucose also had higher mortality rates. The relationship between glucose variability and mortality was unaffected by hypoglycaemia, organ failure, frequency of glucose testing, or medication use.