Impact of Sexual Abstinence Period on Lipid Profiles and Dna Fragmentation Index for Oligozoospermia Patients

Abstract

Background: Oligozoospermia is a common cause of male infertility, and although the duration of sexual abstinence is known to impact the quality of semen, its correlation with biochemical indicators such DNA fragmentation and lipid levels is still being investigated.

Objective: This study examines the effects of different durations of sexual abstinence on sperm DNA fragmentation index, lipid profile markers, and important semen features in men with oligozoospermia.

Methods: Forty-four men who were infertile and had aberrant semen profiles were divided into two groups according to how long they had been abstinent: two to three days (n = 21) and four to seven. Standard procedures were followed to quantify the characteristics of semen, and blood tests were performed to measure DNA fragmentation index (DFI), low-density lipoprotein (LDL), triglycerides (TG), and total cholesterol (CHO).

Results: Higher round cell count (P=0.017) and significantly superior sperm morphology (36.38% vs. 31.13%, P=0.013) were linked to shorter abstinence (2–3 days). There was an increase in semen volume with longer abstinence (4–7 days) (P=0.035). There were no discernible variations between the groups in terms of DNA fragmentation, lipid markers (TG, CHO, LDL), sperm concentration, or motility (P>0.05).

Conclusion: In oligozoospermic men, the length of sexual abstinence does not seem to substantially change lipid metabolism or sperm DNA integrity, while