Measuring the Effectiveness of the Active Ingredient in the Drug Histadine by Ultraviolet Spectroscopy and Comparing the Results with Previous Studies

Abstract

An accurate, simple and sensitive spectroscopic method was developed to measure the percentage of the effect of the active substance loratadine, which is included in the compositions of most antihistamine pharmaceutical compounds, including the drug histamine, which is used to treat seasonal allergies and colds in the form of runny nose and sneezing, and also to relieve and calm the symptoms of urticaria, or what is known as skin urticaria, resulting from contact with irritating substances or exposure to different temperatures, in its pure form and in pharmaceutical preparations. ، The effectiveness of loratadine was measured by replacing the drug tablets after converting them into powder using( )
First: Ethanol and acetone alcohol in a ratio of 1:1. The ultraviolet spectrometer recorded a decline in determining the calibration curve and the curve did not reach the zero percentage, which made it impossible to measure the effectiveness of the drug.
Second: Using 100% distilled water, the pure substance was replaced, as well as in its pharmaceutical form. The device recorded a calibration curve and the percentage of loratadine effectiveness and its solubility in distilled water. The percentage ranged between 1-300 nanometers.
The results indicated that there were no interferences of excipients in the process of measuring the effectiveness of loratadine. The method was successfully applied to measure the dissolution rate and effectiveness of the drug compound in pharmaceutical preparations.